Serious systemic effects may occur before this time, as the venom spreads throughout the body in minutes.

Nasal administration can be used to deliver drugs for either local or systemic effect.

Medicine on the skin of a human being rarely has any systemic effect.

The exact mechanism behind this systemic effect remains to be elucidated.

Minimal local tissue damage and no systemic effects were reported.

It is poorly absorbed and has no systemic effects.

They may exert their effect locally or produce systemic effects.

And an excess of fluoride must have a systemic effect elsewhere in the body.

The topical steroids break down before they can have systemic effects.

An overdose of dextropropoxyphene may lead to various systemic effects.