Some studies suggest that long-term use could cause systemic absorption that leads to tissue accumulation of the substance.

Other adverse reactions due to systemic absorption, such as hypoglycaemia, rash, and acute renal failure, are rare.

This is to ensure that tyrothricin will not come into contact with the bloodstream, therefore limiting the risk of systemic absorption.

In contrast, a comprehensive review of the medical literature from 2011 says that no evidence of systemic absorption can be found in the literature.

After the intake of azo-bound drugs, the mucosal concentrations are very low despite a low systemic absorption.

Like neomycin, it has poor systemic absorption.

Hydrolysis of DEP also takes place at the kidney and liver after systemic absorption.

Topical cidofovir may result in systemic absorption and be associated with renal toxicity (914).

Docusate sodium causes increased systemic absorption of mineral oil.

Caution: May increase the systemic absorption of mineral oil when administered together.