He said he knew of nothing published in any reputable journal to support such an effect.

Research does not support a helpful effect of CoQ10 in periodontal (gum) disease, muscular dystrophy, or exercise recovery.

However, the clinical trials which had supported a protective effect of antiepileptics were uncontrolled; in later, controlled trials the drugs failed to demonstrate an antiepileptogenic effect.

Nor did the data support an effect of clinician gender or age on diagnosis.

Although there are tentative data linking low levels of vitamin D to asthma, there is inconclusive evidence to support a beneficial effect from supplementation.

We found insufficient evidence to support an interventional effect of male circumcision on HIV acquisition in heterosexual men.

Evidence however does not support a significant effect from this practice.

There are some data that support an effect of tamoxifen on upregulation of TGF-βs in vivo in humans.

The data do not support a strong effect on major depressive disorder or even on mild to moderate depression.

For developmental effects, although the available study has important limitations, the overall weight of evidence supports an effect of TCE on cardiac development.