However, while subtle defects do not affect growth, they do result in future varying forms of genome instabilities.

The circling behavior could be due either to ongoing aberrant Wnt activity in the adult brain, or to subtle developmental defects that are not easily detectable microscopically.

We suggest that in an in mutant there is a subtle defect in a cytoskeleton-organizing center that promotes lateral outgrowth.

Other contributing factors include exposure to carcinogens (cigarette smoke for lung cancer), or living for years with subtle immune defects.

They rely on recent sales of similar houses but they suspect that a house that hasn't been sold in recent years may have subtle defects in location or condition and tend to undervalue it.

And CT scans, ultrasounds, M.R.I. and PET scans let doctors define subtle structural defects deep inside the body.

"The Eichner radiation caused subtle, random genetic defects in all of your unreleased ova."

There remains, of course, the possibility that the observed prayer effect was due to some subtle defect in the study's design or to pure chance.

But Dr. Zirkin said several hundred animals was not enough to pick up a rare or subtle defect.

Infants who die in their sleep of no apparent cause often have subtle defects in an area of the brain that regulates breathing, heart rate and arousal, doctors are reporting today.