But on balance, extremists have lost strength in a nation occupied with a substantive challenge.

A 'Pretty Good' Climate "It's a whale of a political challenge as well as a substantive challenge," said Senator Wyche Fowler Jr., a Georgia Democrat.

I have a substantive challenge: What should the formula be for the distribution?

While a chorus of discontent has swelled recently about the fairness of the fund, Cantor's report represents the most substantive and serious challenge yet to the basic rules underlying the fund.

On the other hand, Dr. Van Sertima said, not all Western scholarship is suspect, and those who are making substantive challenges to it "must be backed up by hard evidence."

Mandatory vaccinations were halted in 2004 by a formal legal injunction which made numerous substantive challenges regarding the vaccine and its safety.

But in 2002, the state Court of Appeals ruled against the real estate agents, and there have been no substantive legal challenges since.

Lying on her side and largely underwater, recovering bunkers from the Costa Concordia will present a substantive challenge to the salvors.

It was the first substantive primary challenge Kolbe had faced since his initial run for the seat in 1982.