Motion picture films have substantially affected the arts, technology, and politics.

However, the turnover is so low that its costs do not substantially affect returns.

The form of communication used can substantially affect the experience of players in the game.

A condition is considered to be serious when it substantially affects the applicant's ability to work within or outside the music industry.

Occasionally, it may be necessary to make a decision that will substantially affect the assets or prospects of the business.

Some chefs believe that the way a fish is handled after being caught can also substantially affect its flavor.

The town was substantially affected by an earthquake on Friday, 24 May 1968.

The meeting had substantially affected his minds and actions.

The status quo substantially affects the outcome of a proposed tax.

Therefore, the global concentration of water vapor is not substantially affected by direct human emissions.