The first major smallpox outbreak among natives was between 1616 and 1619 in Massachusetts.

In April 1903, school was prohibited due to a smallpox outbreak.

The smallpox outbreaks from 1837-1840, had a 90% death rate among the infected.

The town was also quarantined in 1882 due to a smallpox outbreak.

The smallpox outbreak in 1518-1519 wiped out much of the region's indigenous population.

Appointed a health officer during smallpox outbreak until resignation 1907.

In 1861 the hotel housed six patients during a smallpox outbreak.

Boston had been plagued by smallpox outbreaks in 1690 and 1702.

For example, a smallpox outbreak in 1518-1519 killed much of the Island's indigenous population.

This year, federal and private officials met to act out how the government would cope with a smallpox outbreak.