Cajal bodies are possibly sites of assembly or modification of the transcription machinery of the nucleus.

This site of modification was found to be the most tolerant position to introduce novel structural changes without impairing biologic activity.

Lysines can be sites of post-translational modification and the conversion of Lysine to an Arginine could affect post translational modification.

Using bioinformatic analysis tools like MyHits Motif Scan and various tools at ExPASy and comparing to multiple sequence alignments, highly conserved potential sites of post-translational modification were identified.

Being located in the metabolic hub, ceramide leads to the formation of other sphingolipids, with the C1 hydroxyl (-OH) group as the major site of modification.

The peptide that changes in mass after reaction with the inhibitor will be the one that contains the site of modification.

It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

U98 belongs to the H/ACA box class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines, the target for this family is unknown.

M1 is a predicted to belong to the H/ACA box class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines.

This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.