NRPSs contain several modules on a single polypeptide.

Unlike most killer toxins, KP4 is a single polypeptide.

In beta sheets, sections of a single polypeptide may run side-by-side and antiparallel to each other, to allow for hydrogen bonding between their carbon backbone.

TRAP is translated as a single polypeptide.

Fission and fusion occurs when partial proteins fuse to form a single polypeptide, such as in nicotinamide nucleotide transhydrogenases.

The two proteins can later fuse together to form a single polypeptide.

It is however first synthesized as a single polypeptide called preproinsulin in pancreatic β-cells.

Voltage-gated sodium channels and calcium channels are made up of a single polypeptide with four homologous domains.

A single polypeptide is made, and is cleaved into individual proteins by viral proteases.

Translation of this fusion gene results in a single polypeptide with functional properties derived from each of the original proteins.