White responded well from this significant setback in the early part of the 1992/1993 season.

These contributed to the first significant setback the Conservatives have suffered since she took office.

Despite this, the company suffered a significant financial setback in 1988.

This was somewhat successful but not without a number of significant setbacks.

The ruling today represents a significant setback to that strategy.

The decline was the first significant setback since the recent rally began.

Thus last night's news could be considered a significant setback.

Civil rights groups tonight criticized the votes as significant setbacks.

That would be a significant setback for the national assembly, which took more than two months just to agree on a new leadership.

The problem was a significant setback to the operation, which had to stop pumping during the winter months.