That lack of trust remains a significant roadblock to progress that could become a focal point of next year's convention.

The most significant roadblock to Hoffa's ascension may be the probe into the finances of his 1996 campaign.

In recent years decisions and state legislation have imposed several significant roadblocks in the path of smokers seeking damages from tobacco manufacturers.

There are significant roadblocks to instituting a playoff system in Division I-A.

Experts said the S.E.C. registration issue would not be a significant roadblock for Google's offering.

Living in an apartment can be a significant roadblock to owning a plug-in hybrid because most manufacturers recommend you don't use extension cords.

When the 7-0 Seminoles face 6-3 Virginia, it will very likely be their last significant roadblock before a Nov. 25 showdown at Florida.

But they do pose a significant roadblock to the expansion of joint programs, a process that many experts say has enhanced the auto industry's competitiveness.

One of the most widely recognized and significant roadblocks to progress is cancer research is the lack of standardized, high-quality biospecimens.

He said each of Dr. Axelrod's initiatives faced significant roadblocks "which may negate" their "quick implementation."