Yet most of Europe has no significant problem with such crime.

However, this was not without significant problems for the industry.

The summer heat was a significant problem for the school.

Any one of those things would be enough to give most people a significant problem.

The F-111 program experienced significant problems during the late 1960s.

However this may cause significant problems if they go out of business.

A significant problem happens to be that people are having less children.

"For many years that worked well with no significant problems," he said.

You may not have significant problems with your vision for many years.

Of course, you're still left with a rather significant problem.