This is the first time I've heard of a significant issue with it.

"School is an appropriate place for the significant issue," he said.

The more significant issue is whether the players take him seriously.

The bill could become a significant issue in the Presidential campaign.

The two companies would also have significant cultural issues to overcome.

As if there are enough powerful women to make that a significant issue.

"It's a significant issue all over the rest of the state."

Some children grow up without race being a significant issue in their lives.

Quality is a very significant issue, whether perceived or real.

"And this is no longer a significant issue for the investigation."