Most errors are minor and do not cause significant harm, but others can have catastrophic consequences.

Now, the agency must prove that significant harm has been caused before it may act.

One dose couldn't cause significant harm, or so he'd hoped.

The concept of significant harm is fundamental to the Act and provides a threshold for legal intervention.

Here, each individual act or continuing infraction may not amount to a significant harm of itself.

But I would not expect another concussion to cause him any significant harm.

Outside that zone, there is little chance of significant harm, they say.

"This has caused significant harm to the reputation of this department."

Instead, it conducted a less comprehensive assessment that predicted no significant environmental harm.

Prostate cancer often grows very slowly and may not cause significant harm.