This represents a significant political difficulty, since there are other member states who support the idea.

This caused him significant difficulties when he tried to correspond with his friends.

Black was clearly better, although I had significant technical difficulties in converting the advantage.

After designing the show, the two had significant difficulties getting the series green lit.

Between 110-190 million people have very significant difficulties in functioning.

He said in a footnote to an order last week that the process "has gone well and thus far without significant difficulty."

It faced significant financial difficulties in 2008 which affected its ability to write new business.

This is an area which the Commissioner will know has caused significant difficulty under the current regulation.

Balsan's death led to significant financial difficulties for the production.

Under both limitations, an action is not required if it results in "significant difficulty or expense. "