His massive frontier district included the historically significant city of Toledo.

He renamed the country's only significant port city after himself.

These factors and others made Eureka a significant city in early California state history.

Eventually it became the most significant city in the region.

Ann Arbor has been said to be the first significant city to lose its only daily paper.

It is well developed, with each of the major islands having at least one significant port city.

By 1900, Denver was a major transportation crossroads and a significant western commercial city.

I-70 does not intersect any significant cities until it reaches Richmond.

Lancaster and York are the other two significant cities in the region.

His marker stopped at a well-known and significant city.