Not only has the government failed to bring many significant cases, it is opposing one brought and won by a third party.

The prevalence of clinically significant cases is 1 per 10,000.

But early indications have been ominous in some of the more significant cases.

"This was a significant case in my professional career," he said.

It is a significant case to study in Canada's legal, political, and social heritage.

Like Nathan, she had never tasted defeat, at least not in any significant case.

Some may be routine, but some have been pretty significant cases.

He had a great record of achievement in some very significant cases.

James was involved in many significant legal cases in the 1930s and won most of them.

He has presided over many other significant cases, both civil and criminal.