Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects.

West Papuans have significant cultural affinities with the inhabitants of Papua New Guinea.

It has no significant affinity for the σ receptor.

It acts as a partial agonist for the androgen receptor with a Ki of 5nM, and no significant affinity for any other receptors tested.

Unlike many other antipsychotics, ziprasidone has no significant affinity for the mACh receptors, and as such lacks any anticholinergic side effects.

It does not appear to have any significant affinity for the D or α-adrenergic receptors.

Unlike the case of the AR, megestrol acetate has no significant affinity for the ER.

It lacks significant affinity for the androgen receptor, and accordingly, does not produce any androgenic or anabolic effects.

None of these compounds have shown significant (sub-micromolar) affinity at the kappa-opioid receptor, and there is no evidence that they contribute to the plant's psychoactivity.

However, baclofen does not have significant affinity for the GHB receptor, and has no known abuse potential.