As with any new technology, there have been more than a few serious setbacks.

This would be a serious setback for American oil interests and investment in that region.

But two weeks ago, the group suffered a serious setback.

"The result was another serious setback for a major artist."

Then, after a serious setback at work, she lost interest in her job.

On the surface, this does not seem to be serious setback because it is early in training camp.

But after it the first serious setbacks of the campaign arrived.

"The Court ruling is obviously a serious setback for us."

Whether today's accident would represent a so serious a setback for the European space program was not clear.

And they did not seem to respond well to serious setbacks.