"You can't come in here and do anything without a serious impact."

This would have a very serious impact on jobs, growth and investment.

"In the short term we would see a serious impact," she said.

This has had a serious impact on how the country is seen from outside.

Military action against Iraq might have a serious economic impact as well.

There has been a very serious impact on the whole social life.

Not getting a good night's sleep can have a serious impact on a child's life and overall health.

The financial crisis has been having a serious impact on the lives of young people.

Poverty has a serious impact on single women with children.