In other words, a structural motif does not need to be associated with a sequence motif.

However, there are sequence motifs within the database that are overrepresented and are found more than 5 times.

This results in a family of orthologous proteins, usually with conserved sequence motifs.

Many members of this family also include two histidines in a sequence motif:

No additional sequence motifs or domains were identified.

The orthologs identified in other species are more varied but still contain components of the sequence motif.

Also, the existence of a sequence motif does not necessarily imply a distinctive structure.

This is also the case for bends induced by proteins binding to specific sequence motifs (61).

Class I has two highly conserved sequence motifs.

This sequence motif is also conserved in other species.