The seed extract is agglutinating.

A dose of 150 mg of a standardized seed extract (IGOB131) twice daily has also been used.

However, many of these products are produced from myrosinase-inactive sprout or seed extracts.

The seed extract standardized to around 20 percent aescin (escin) is used for its venotonic effect, vascular protection, anti-inflammatory and free radical scavenging properties.

Many utilize seed extract, minerals, and other chemicals to achieve these results.

High doses of the seed extract show an anti-inflammatory effect in studies in rats and mice.

Some folklore regards the seeds as poisonous, but tests of seed extracts reveal no toxicity to mice, even in doses up to 2500 mg/kg.

Natural Standard Patient Monograph: "Grape seed extract."

Not enough is known about the safety of using horse chestnut seed extract from which the poisonous esculin has been removed during pregnancy or breast-feeding.

The seed extract is used as a bio fuel to generate thermal electricity and to power motor engines for trucks and buses.