Aciclovir has a high distribution rate; protein binding is reported to range from 9 to 33%.

Hypocalcaemia (low calcium) is also seen due to poor absorption of vitamin D and calcium, and secondary to low protein binding of calcium.

If the protein binding is reversible, then a chemical equilibrium will exist between the bound and unbound states, such that:

Ceftriaxone has the additional complication that the protein binding is non-linear, saturating at high concentrations.

Most plasma substances have primarily their free concentrations regulated, which thus remains the same, so extensive protein binding increases total plasma concentration (free + protein-bound).

The protein binding is 40%.

The option of non-linear (saturable) protein binding is also included.

Due to the high protein binding of the chemical the drug is not effective against E. coli and is not effective against Pseudomonas spp.

About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent.

Astemizole is rapidly absorbed from the gastrointestinal tract; protein binding is around 96 percent.