There was further evidence of the proliferative effects of the endothelins.

PLC- γ is vital to the proliferative effects of VEGF-A signalling.

The proliferative and chemotactic effects of HB-EGF results from the target influence on particular cells including fibroblasts, smooth muscles cells, and keratinocytes.

Certain foods such as soy may also suppress the proliferative effects of estrogen and are used as an alternative to hormone therapy.

As a result of activation of the ERβ, 3β-diol has antiproliferative effects against prostate cancer cells and proliferative effects on breast cancer cells.

It has anti-apoptotic as well as proliferative effects.

Estrogens have a hypertrophic and proliferative effect on mucosa by reducing the desquamating effect on the superficial layers.

It has pronounced progestogenic effects and opposes the proliferative effects of estrogen in the utereus, but lacks anabolic, androgenic, estrogenic and corticoid activity.

Sole therapy with estrogen is contraindicated if the uterus is still present due its proliferative effect on the endometrium.

The estrogen-alone trial, performed on women who were post hysterectomy, due to the proliferative effect of the hormone on endometrial tissue, did not show such problems and was continued.