People with dementia can have profound problems remembering even basic words.

But no solution to any profound social problem is perfect.

Only Tupuna appreciated the profound problems which the next few hours would bring.

It would be a profound problem in a different year.

"In this sense it is not a very profound problem" he said.

At the same time, the author is commenting on some of the most profound problems facing modern medicine.

Finally there is the most profound problem of all, the environment.

"But regarding many of the state's most profound problems, he was not prepared to lead."

No one can have an instant cure for a problem so profound.

Campaign finance is a profound problem for the survival of American democracy.