Even Amhuluk's presence hadn't held the bone-draining chill that was death in such a profound manner.

For biologists, the severity and the pattern of the birth defects provides striking evidence that retinoic acid modulates development in a profound and specific manner.

The new global economy of the 21st century has transformed the economic, social, educational and political landscape in a profound and indelible manner.

He is also more of a pacifist and he often speaks in a profound and meaningful manner, giving him a rather preachy presence among other people.

This is true in that mathematics "makes sense" in a very profound manner.

In so doing, they desecrate our flag in a far more profound and lasting manner than a handful of flag-burners could ever hope to accomplish.

That is why the not-doing of it is probably the most profound manner in which we honour our biological progenitors.

This column suddenly appreciates its readers in a far more profound manner.

Their interest had to be genuine, and that flattered him in a profound manner.

In some profound manner," he writes, "the organization I had been willing to pledge my life to was wrong.