That "a failure to accurately reflect the Bay Area in a cultural way is a profound failure."

It is a sad illustration of our profound political failures.

Video (6min 12sec), 10 Sep 2011: 10 years of terror: Our response to 9/11 represents a profound failure of the political and philosophical imagination.

But the most profound failure was that of the C.I.A.'s top managers, the inspector general concluded.

His crucial misstep appears to have been a profound failure to blend in.

This was a profound failure.

He brought out some patients in profound pulmonary failure.

"It reflects a profound failure of an effort by the court to conduct a fair proceeding," Mr. Clark said.

But that only points to a profound and long-term failure in British politics.

The wound was still open, the sense of failure profound.