He had made a profound error.

It would, however, be a profound error to view increases in a company's value as concern just for the shareholders.

A pity it's such a profound error.

And you have made a profound error.

The sterilization procedure against your ship was a profound error.

Although the report does not single out individuals, it states that "profound errors in judgment" were made over the years.

It would have been a profound error.

Too many profound errors were made.... Well act this morning as your intermediary.

This would be a profound error: Hamas is essentially a terrorist organisation.

The Independent, in a front-page editorial, said that "profound errors of judgement are about to be made."