As an analysis by the Federal Communications Commission concluded, the radio industry was in "profound financial distress."

He was in no state to think, to form opinions, or to withstand such profound emotional distress.

She left her chair and displayed profound distress as she stamped about the room.

They were large, brown, pretty, and full of the same profound distress Alvarez had confided in the anteroom.

They are expected responses to profound distress; though dysfunctional, they provide relief.

"You are in profound distress," he said to her.

The slave Skkukuk saved Pyanfar's life in the riot, to her profound distress at the debt.

Using cognitive behaviour therapy in the treatment of profound existential distress.

"I can't understand you," said Margaret, in the profoundest distress.

This is the first opportunity I have to mention to colleagues my profound distress at the matter.