The new government, based in Hanoi, was confronted with many profound difficulties.

Among our most profound difficulties is making them work together.

If there is a way past those profound difficulties, it must begin with realism.

Despite his youth, the boy encountered profound difficulties with the simplest visual perceptions.

Japanese who are captured in Iraq will, despite their good intentions, create profound difficulties for themselves and their families.

Unless it is correctly early with hearing aids, such loss can lead to profound difficulties with speech and language.

Physicians face some profound moral difficulties in their inability to address this issue themselves.

While relations with Israel are pressing, his most profound difficulties are internal.

There are profound difficulties in getting to know the music of another culture; it is hard enough to know one's own.

First Federal Bank was not the only bank to experience profound difficulties with it's customers.