But the potential for the government's proposals to inflict profound and lasting damage on our natural landscape makes this a fight we need to win.

It was difficult, if not impossible, to leave the orbit of a supernova without incurring profound and permanent damage.

We Humans found that the DemoPol does profound damage to social relationships.

I can't see any other way of resolving the situation without causing the most profound damage to yourself.

A package on its way from a warehouse to a store may encounter bumps that can cause profound damage to its contents.

They say they suffered profound psychological damage as a result.

"The most profound damage Kinsey did was to kids," he says.

Some seem to have suffered profound damage.

The economic separation itself then did profound damage to the world payments and trade systems.

The creation of a precedent would do lasting and profound damage to the credibility of the European Union.