And this had profound consequences for the functioning of each system.

It will be an announcement with profound public health - and political - consequences.

This eye and taste of a 19-year-old had profound consequences for network television.

Her first brush with fame had profound political consequences of course.

Such a change would have profound consequences for the global climate.

Words and their meanings have profound consequences, especially to young children.

It's an economic and social question with profound political consequences.

It is the first study to document the profound social and economic consequences of obesity by following a population for years.

"I had no idea that there would be such profound consequences."

This friendship was to later have profound consequences for both of them.