Native Americans both on and off reservations continue to face many profound social and economic challenges.

From religion in space to digital immortality, the future is full of profound challenges and astonishing opportunities.

I think it is the most profound challenge of the new millennium.

But the vast opportunities in the deep-water gulf are accompanied by profound challenges.

These demographic factors describe the dimensions of an acute national problem and indicate the profound challenge before us.

I am a religious artist, and art in a Christian context is a profound challenge.

The Clinton legal position poses a profound challenge to Congress.

"The most profound challenges facing American employers are the learning deficit and the low productivity in the workplace," the study said.

As a community of nations we face three profound challenges:

But, of course, we must first wake up and see this profound challenge in front of us.