The lung is frequently the site of second primary malignancies in patients with primary lung cancers.

No survival advantage has yet been demonstrated, however, in part due to recurrence and death from the primary malignancy.

The most common site for a second primary malignancy is the gastrointestinal tract.

It is usually a primary malignancy, the initial place from which a cancer spreads in the body.

Of 18,207 men with prostate cancer, 560 developed a second primary malignancy.

Adenocarcinomas are more common primary malignancies of the appendix than carcinoids.

Once the cytology has been confirmed, the management strategy depends on the underlying primary malignancy and the number and type of previous therapies.

The incidence of second primary malignancies is less than after treatment of tumors at other head and neck sites.

Recurrences after 5 years are rare and usually represent new primary malignancies.

Noninvasive imaging studies are commonly used during the workup of primary malignancies.