She does not know the practical difference between the two, if any.

Of course, I couldn't see that it made any practical difference.

Not that it made any practical difference what kept the survivors coming.

It doesn't make any practical difference as we go through our lives.

Compared to the visual and practical differences these sort of changes make, the cost is small.

Less clear is whether they are making any practical difference.

How much practical difference it would make is less clear.

How much practical difference the distinction makes remains to be seen.

"Do you think it makes much practical difference to the animal in question?"

The only practical difference is how polite I've got to be.