Thus, X-linked mutations tend to be rare in women.

The mutations in the protein tend to cause the production of a shortened protein.

The mutation is believed to have started in Germany, and tends to be local to that area.

However, infrequent mutations that provide a survival advantage will tend to clonally expand at the expense of neighboring cells in the tissue.

Truncated (shortened) mutations of LIS1 tend to cause severe lissencephaly.

However, somatic mutations tend to cluster in a limited number of signalling pathways, which are potential treatment targets.

This mutation also tends to affect younger individuals.

In these cases a mutation will tend to become more common in a population through natural selection.

"Most mutations tend to be 'self destructive'," I answered.

These mutations tend to cluster in one of three domains within the protein, designated MH1-3.