One reason is that many mature cells live too short a time to develop the string of mutations required to make a cell cancerous.

Net1N(7m) contained mutations required to strongly inhibit Plx1-dependent disruption of Net1N-Cdc14 complexes, whereas Net1N(19m') contained additional mutations without compromising the affinity of Net1N to Cdc14 [ 25 ] .

Producing such an optimal multiple sequence alignment is usually determined with a dynamic programming algorithm that finds the most probable evolutionary outcome by minimizing the number of mutations required.

The mutations required for immortality can occur naturally or be intentionally induced for experimental purposes.

Behe claims that the mutations required for speciation are not possible without design, and that this is the "edge of evolution".

Creationists also argue that genetic mutations are strong evidence against evolutionary theory because the mutations required for major changes to occur would almost certainly be detrimental.

Cancer cells must be capable of continuous proliferation and self-renewal in order to retain the many mutations required for carcinogenesis, and to sustain the growth of a tumor since differentiated cells (constrained by the Hayflick Limit) cannot divide indefinitely.

Secondly there is a genetic barrier to INI resistance, defined by the number of mutations required for the loss of clinical INI activity.

Behe has stated that the results of the paper support his notion of irreducible complexity, based on the calculation of the probability of mutations required for evolution to succeed.

Moreover, the reasoning for combining antivirals is that the mutations required to produce resistant H.I.V. strains will debilitate the virus's ability to reproduce itself.