Of the four, Guinness was the one who had the most substantial and successful film career.

This is the most substantial movement, in very fast tempo.

The most substantial factor in the losses was fuel costs.

It is certainly the most substantial game for the Wii.

They were among the most substantial to have fallen, according to the Engineer records.

If built, it would be the most substantial and enduring link between the countries.

The town grew and became the most substantial in the district.

That is perhaps the most substantial policy difference between them.

This painting was to be his largest and most substantial work.

"They're among the most substantial I've had in 28 years of doing this."