In their view, torture was the most efficacious means of casting out the Devil from the person they were questioning.

It had been the proper insult at the most efficacious moment.

Now that you are here I shall endeavor to make the most efficacious use of your talents.

He insisted on an assault across the English Channel as the most efficacious means to that end.

I have a most efficacious invention that will circumvent such tiresome duty.

She replies, with a face that must be straighter than her tongue: "How to position yourself in the most efficacious way."

With her self- control, she would lose her most efficacious weapon.

Driving a stake through the heart or cutting off the head were considered the most efficacious methods.

It was one of the most efficacious of the surface songs.

At present, the most efficacious treatment regimen, if any, is unknown.