The cause of the ancient pestilence was to be the world's first species made extinct by design rather than accident.

Had the destruction gone ahead, smallpox virus might have been the first to be made extinct by human intervention.

And what price do you place on the species made extinct in the rainforest?

The baronetcy was made extinct on Sir George's death in 1658.

The film depicts a future in which all plant life on Earth has been made extinct.

Four bird species had been made extinct on the island.

It is the only British bird made extinct in historic times.

It may have been made extinct by construction on Interstate 5.

The St. John's dog was made extinct in its homeland by a combination of two factors.

The others were likely all made extinct by a combination of excessive hunting and deforestation.