Kumble claimed that he knew through experience that such an allegation would have major ramifications both on and off the field.

The research had major ramifications in the field of liver transplantation.

Such shifts can have major ramifications for stores operating at the margins of profitability.

Historians suggest the contact had no major cultural ramifications for either side.

The incident had major political ramifications.

Even so, he said, the commission's proposals will have major ramifications for the industry, Mr. Henderson said.

But while property taxes are principally a local issue, they have major political ramifications in state capitols.

"If we can nail down the connection between herpes and atherosclerosis, then this discovery will have major, major ramifications."

That is what we are facing here: a worldwide crisis which has major ramifications for Europe.

This was a plot point that would have major ramifications in later years.