I-40 is the only major Interstate that runs through the county.

The valley is also crossed by two major interstates and their auxiliaries.

Akron is served by two major Interstates that bisect the city.

Mexicali is located at a Junction of major interstates and federal highways.

Harrison County is bisected by the major east-west Interstate 64.

Although towtrucks were immediately dispatched to the affected areas, the traffic on all major Interstates had not yet resumed as of press time.

Your major interstates are going to get the most attention because they're the most visible and the most used.

Drifting snow and poor visibility closed roads throughout the region, including parts of two major interstates, 25 and 70.

I-69 is well on its way to becoming another major north-south Interstate in Kentucky as parkway upgrade studies are complete.

Miller Beach lies near the nexus of four major interstates: 65, 80, 90, and 94, although none of them pass directly through the neighborhood.