In "The Memphis Record," Presley groped toward artistic maturity by emoting with a burly, stern aggression that largely precluded the old joking self-caricature.

Technically, Dor Yeshorim only provides the testing service, and while two people may marry even if both individuals are informed that they are carriers for the same disease, communal pressure largely precludes this.

Multimedia codecs are highly proprietary and suffer from serious patent-encumbrance issues that largely preclude open source implementations.

Since re-activation, operational tempo has largely precluded the re-establishment of this practice.

LPFM licenses are normally issued to non-commercial educational entities (such as schools or municipalities) and are subject to strict requirements largely precluding multiple stations under common ownership.

The northern-most one is administered by Anza-Borrego Desert State Park and largely precludes the use of motorized vehicle except street legal and then only for basic access to the canyon floors.

No doubt Shostakovich's proximity and the darkness of his time and place keep musicians from slipping into superficial sweetness, although his penchant for steely melodies and bitter harmonic twists largely preclude that in any case.

Tori-san deserved to be up there with the real musical geniuses who lived before the Age of Celebrity came along to largely preclude most peoples' chances of achieving real greatness.

He had found that his teaching responsibilities at the Carnegie Institute largely precluded him from doing research.

The animals that entered into a symbiosis with humans are now biologically adapted to a way of life that largely precludes a return to their predomesticated ways.