The issue "caused people to increasingly question or doubt" their future role, this person said.

But some potential issues caused us to figure out a new name, and quick.

Q. What larger economic issues cause concern for your company?

This time, the issue of character caused her to turn against the Republicans.

"This issue was causing enough concern among employees that he wanted to deal with it."

Often, an underlying medical issue causes a change in behavior.

Secrets and issues about who should lead the group causes problems.

On the other hand, just these few issues caused huge problems, owing to differences in approach.

The issue would cause a heated debate even in Parliament.

Several years later, legal issues would cause litigation in the Texas courts.