In each of the following examples it is possible to identify some random events that disrupted the ongoing course, with irreversible consequences:

A stay pending appeal is necessary to prevent these far-reaching and irreversible consequences of a profoundly flawed ruling.

Traditionally, the loss of muscle mass had seemed an inevitable and largely irreversible consequence of aging.

Kirk and the three others probably could have taken the Proctor squad in hand-to-hand, but it might have led to potentially irreversible consequences.

Of all those who tampered with time, she was the only one who seemed concerned that what they had done may have had irreversible consequences.

The irreversible genetic consequences of this mixing may well prove fatal to the wild salmon of Norway.

If an immediate halt to the current cycle of violence is not achieved, the situation may spiral out of control, perhaps with irreversible consequences.

In this way, prevention can be strengthened and irreversible consequences avoided.

As a doctor, I would also like to say that drug abuse can have extremely grave and irreversible consequences for human health.

They must realize their decisions could have irreversible consequences.