The detailed lineage of blood cells is not fully worked out but it is quite clear that there is, with successive cell divisions, an irreversible commitment to one or other general pathway.

Emissions of GHGs are a potentially irreversible commitment to sustained radiative forcing in the future.

In his five-minute speech, Mr. Arafat sounded a far more conciliatory tone than during his last visit, emphasizing that the Palestinian people maintained an irreversible commitment to peace with Israel.

Governments may be able to finance tidal barrage power, but many are unwilling to do so also due to the lag time before investment return and the high irreversible commitment.

Any irreversible and irretrievable commitments of resources that would be involved in the proposed action should it be implemented.

This feed forward control theme is commonly observed in hematopoietic cell lineage development, where irreversible commitments are made.

On March 17 he had apologised publicly to the "victims of deplorable and regrettable incidents" under his regime, stating that he now had "a profound, sincere and irreversible" commitment to reform.

Each additional step upward was an irreversible commitment to this single option.

We have made an irreversible commitment to reforming our judicial system and, through strong collaboration with European institutions, we created and are now funding a comprehensive multi-year programme.

This seems to be the motto of our politicians, who are caught up in the spiral of their so-called irreversible commitments to the single currency.