A signaling molecule initially binds to a receptor on the surface of the cell, which stimulates the activation of immediate early genes and second messenger molecules.

After complement proteins initially bind to the microbe, they activate their protease activity, which in turn activates other complement proteases, and so on.

These form part of the moving junction which initially binds to the erythrocyte surface and is involved in the entry of the parasite into the erythrocyte cytoplasm.

On 12 August, Triumph stood out of Pearl Harbor with a convoy bound initially for the Solomon Islands.

The tetanus toxin initially binds to peripheral nerve terminals.

Type 1 fusion machines initially bind a receptor on the target cell surface, which triggers a conformational change, allowing for binding of the fusion protein.

A ligand initially binds to the β-pleated sheet, and through allosteric regulation causes the movement to an α-helix toward the β-pleated sheet.

LFA-1 is the first to bind T-cells to antigen-presenting cells and initially binds weakly.

When an aminoacyl-tRNA initially binds to its corresponding codon on the mRNA, it is in the A site.

The sugar initially binds to the first greasy residue with van der Waals forces.