Although there is no 'explicit sandbox' mode, Chahi stated that each mission features a distinct map, which the player can return to and manipulate further.

Off-label use of the oral drug ketoconazole is sometimes used as a way to further manipulate hormones with a therapeutic effect in CRPC.

She further manipulated Emily into meeting Tug, letting him believe he was responsible for Emily's pregnancy.

Despite this and other similar actions, she remains an object of Kanta's desires, which she uses to further manipulate him.

The Garridos further manipulated Dugard by presenting her, on two occasions, with kittens that would later "mysteriously vanish."

Later, generals and Caesars further manipulated these numbers with double and half-strength units.

After recording the basic sounds, the Barrons further manipulated the sounds by adding other effects, such as reverberation and delay, and reversing or changing the speeds of certain sounds.

Saturn Queen further manipulates events to place him in charge of Kandor and mind controls Kara Zor-El (Supergirl) into marrying him.

Using their own proprietary technologies, both Faroudja and Snell & Wilcox also further manipulate the line-doubled picture, to enrich it.

The outer membrane can also be used to further manipulate diffusion/partitioning of the analyte into the biolayer so that the influence of external physical and chemical variables is diminished.