He begins by questioning the adequacy of their measurement of the functional importance of positions.

Cyclin D is one of the major cyclins produced in terms of its functional importance.

It is well established that such effects occur to some degree, but their functional importance has long been a matter of controversy.

Frequently the primary structure encodes motifs that are of functional importance.

Much controversy has centred on the concept of 'functional importance'.

The problems involved in assessing 'functional importance' render the concept highly dubious sociologically.

Similarly, some people have access to unequal reward, not because of any talent or functional importance, but by accident of birth.

These conserved sequences are assumed to be of functional importance within related proteins.

This level of conservation suggests functional importance.

In particular, this analysis has revealed 17 residues of that may be of functional importance in catalysis.