The degree of this bias will depend on the protein family and the corresponding functional constraints on the amino-acid sequence.

Regions of each protein have differing functional constraints (features critical to the structure and function of the protein).

Lest this account seem unduly cynical, it must be added that the individuals involved are subordinate to the functional constraints of their job.

As Rupert Riedl pointed out, this degree of functional constraint - or burden - generally varies according to position in the organism.

Dress reform was seen as essential in liberating women from the functional constraints imposed on their activities by conventions reinforcing a male dominated society.

Some of these behaviors could be explained by functional and financial constraints, as well as personal or lifestyle choices.

His is the artist's approach free of the functional constraints and yet must reach out for something else.

Thus we favor the interpretation that increased rates of amino-acid substitution in predicted genes results from lower levels of functional constraint.

Intron sequences may be conserved, often because they contain expression regulating elements that put functional constraints on their evolution.

The most basic criterion for a successful design is that it satisfies the functional constraints imposed.